![]() Avastin (bevacizumab): Avastin was originally developed as a cancer treatment to destroy tumor blood vessels.Vabysmo (faricimab-svoa): Vabysmo is a new option for wet AMD that treats the condition in two different ways.Beovu (brolucizumab): Beovu injections can last for as long as 3 months.Eylea (aflibercept): Eylea is a longer lasting option.Lucentis (ranibizumab): Lucentis was the first anti-VEGF medication approved to treat wet AMD.You and your doctor can talk about which medication might work best for you. Their primary differences are the dosage and how often you’ll need to receive the injections. All these medications are administered as an injection to stop the growth of blood vessels. There are a few types of anti-VEGF medications. They’re also not recommended for people with advanced wet AMD who have lost the majority of their vision. VEGF is a substance in your eye that produces healthy blood vessels.Īnti-VEGF injections aren’t suitable for everyone with macular degeneration. The injections have a medication called anti-VEGF. These painless injections are administered directly into the eye, into the clear, gelatinous area called the vitreous. Intravitreal injections are a treatment option for wet AMD. Anti-VEGF injections can slow this process and may help prevent some vision loss. These vessels can leak and bleed, causing damage to your central vision. If you have wet AMD, it means that abnormal blood vessels are expanding underneath the macula. How does Eylea compare to other drugs?Īvastin is a much cheaper drug than Eylea, but it is not recommended by NICE as a DME treatment – although the National Eye Institutes reports that the drug offers similar benefits to Eylea for DME patients.Īvastin has not been approved because Novartis, the makers of the drug, currently make more profit from the other anti-VEGF drug they make, LucentisĮylea and Lucentis were compared in a 2015 study in treatment-naïve patients with neovascular age-related macular degeneration (nvAMD), but both were deemed to have similar effects.About anti-VEGF injections for macular degeneration Some of the more serious, albeit rarer side effects that can occur from Eylea treatment include retinal detachment and infection inside the eye. How much does it cost?Įylea costs £816 per vial (according to the NICE technology appraisal 294) and the total cost for treating a patient in the first year is estimated at just less than £7,000, which is based on 8.5 injections. Treatment with Eylea should be discontinued if the patient is not receiving any benefit. This decision would be based on the effect the drug has on a patient’s vision. Patients are given a single 2mg injection of Eylea every month for five consecutive months, followed by one injection every two months.Īfter the first 12 months, this treatment interval could be extended depending on its success. NICE recommends that DME patients should be able to receive Eylea on the NHS if the central retina of their eye is 400 micrometres thick or more before treatment. NICE approvalĮylea was approved by the European Medicines Agency for treating DME in 2014 and received approval from the National Institute for Clinical Excellence (NICE) in 2015.Įylea was granted NICE approval following successful results from two phase II studies – VISTA and VIVID – that showed Eylea improved best corrected visual acuity (BCVA) amongst the majority of participants compared to laser treatment, which is the first line of treatment for patients with DME. It is intended for use alongside appropriate measures to control blood sugar levels, cholesterol and blood pressure. Other anti-VEGF drugs include Lucentis (ranibizumab), which is approved in the UK for patients with DME and impaired vision.Įylea is marketed in the UK by Bayer and administered to patients by injection through the white of the eye into the fluid within the eye. Drug class: Anti-vascular endothelial growth factorĮylea is a vascular endothelial growth factor (anti-VEGF) drug – this is a drug class that reduces the formation of abnormal blood vessels that damage the retina.Metformin: Uses, Dosages, Interactions and Side EffectsĮylea, the trade name of aflibercept, is recommended as a potential treatment for some people with diabetic macular edema (DME).ĭME is a form of diabetic retinopathy that occurs when abnormal blood vessels grow on the surface of the retina, leading to vision problems.Hyperosmolar hyperglycemic nonketotic syndrome.How to bring down high blood sugar levels.
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